Blar i forfatter "Vårtun, Åse"
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Agreement between anatomical M-mode and tissue Doppler imaging in the assessment of fetal atrioventricular annular plane displacement in uncomplicated pregnancies: A prospective longitudinal study
Zanardini, Cristina; D'Antonio, Francesco; Hvingel, Bodil; Vårtun, Åse; Prefumo, Federico; Flacco, Maria E.; Manzoli, Lamberto; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-23)Aim To evaluate the level of agreement between M‐mode and pulsed‐wave tissue Doppler imaging (PW‐TDI) techniques in assessing fetal mitral annular plane systolic excursion (MAPSE), tricuspid annular plane systolic excursion (TAPSE) and septal annular plane systolic excursion (SAPSE) in a low‐risk population. Methods This prospective longitudinal study included healthy fetuses assessed from 18 to ... -
Agreement between preload reserve measured by impedance cardiography and echocardiography during pregnancy
Liang, Huan; Vårtun, Åse; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-05)<i>Purpose</i>: Accurate assessment of cardiac function is important during pregnancy. Echocardiography and impedance cardiography (ICG) are commonly used noninvasive methods to measure stroke volume (SV) and cardiac output (CO). The diference in stroke volume (ΔSV) or cardiac output (ΔCO) measured at baseline and after passive leg raising (PLR) is a measure of preload reserve that predicts volume ... -
Differences in gene expression between first and third trimester human placenta : a microarray study.
Sitras, Vasilis; Fenton, Christopher Graham; Paulssen, Ruth H; Vårtun, Åse; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)The human placenta is a rapidly developing organ that undergoes structural and functional changes throughout the pregnancy. Our objectives were to investigate the differences in global gene expression profile, the expression of imprinted genes and the effect of smoking in first and third trimester normal human placentas. Placental samples were collected from 21 women with uncomplicated pregnancies ... -
Effect of Passive Leg Raising on Systemic Hemodynamics of Pregnant Women: A Dynamic Assessment of Maternal Cardiovascular Function at 22–24 Weeks of Gestation
Vårtun, Åse; Flo, Kari; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Longitudinal reference ranges for maternal plasma laeverin, and its role as a potential biomarker of preeclampsia
Nystad, Mona; Sitras, Vasilis; Flo, Kari; Widnes, Christian; Vårtun, Åse; Wilsgaard, Tom; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-25)Background: Laeverin is a placenta-specific membrane-bound aminopeptidase. In this study we wanted to: 1) serially measure plasma levels of laeverin in healthy women during the second half of pregnancy and postpartum, 2) determine whether laeverin is differently expressed at 22–24 weeks in women who later develop preeclampsia compared to controls, 3) compare laeverin protein expression in placenta ... -
Maternal cardiac function, uterine artery hemodynamics and natriuretic peptides at 22-24 weeks of gestation and subsequent development of hypertensive disorders of pregnancy
Liang, Huan; Vårtun, Åse; Flo, Kari; Widnes, Christian; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-26)<p><i>Introduction - </i>Maternal cardiac dysfunction as well as abnormal uterine artery (UtA) Doppler are associated with hypertensive disorders of pregnancy (HDP), but their relation is unclear. We investigated the correlation between maternal cardiac function, UtA hemodynamics and natriuretic peptides, and explored differences between women who subsequently developed HDP and those who did ... -
Maternal functional hemodynamics in the second half of pregnancy: A longitudinal study
Vårtun, Åse; Flo, Kari; Wilsgaard, Tom; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-10)Objective: Cardiovascular response to passive leg raising (PLR) is useful in assessing preload reserve, but it has not been studied longitudinally during pregnancy. We aimed to investigate gestational age associated serial changes in maternal functional hemodynamics and establish longitudinal reference ranges for the second half of pregnancy. Materials and Methods: This was a prospective ... -
Maternal plasma pro-atrial and C-type natriuretic peptide levels and their associations with cardiovascular and renal function in the second half of normal pregnancy: a longitudinal study
Yarlagadda, Rima D.; Johnson, Jonas; Vårtun, Åse; Flo, Kari; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-05)Background - Physiological adaptation in pregnancy is characterized by remodeling of endocrine, cardiovascular and renal functions leading to fluid retention, volume expansion, altered cardiac loading conditions and hyperdynamic circulation. Natriuretic peptides have been used as biomarkers of cardiovascular function, but their associations with gestational age-related changes in maternal cardiac, ... -
Nitric oxide, oxidative stress and streptococcus mutans and lactobacillus bacterial loads in saliva during the different stages of pregnancy: A longitudinal study
Wagle, Madhu; Basnet, Purusotam; Vårtun, Åse; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-03)Hormonal changes associated with pregnancy promote oral bacterial growth, which may affect salivary nitric oxide (NO) levels, oxidative stress (OS), and antioxidant capacity (AC). We hypothesized that caries-related bacterial load, NO level, and OS in the saliva change with advancing gestation. The aim of this study was to investigate longitudinal changes in salivary NO, OS, and AC during pregnancy ... -
Oxidative stress levels and oral bacterial milieu in the saliva from pregnant vs. non-pregnant women
Wagle, Madhu; Basnet, Purusotam; Vårtun, Åse; Trovik, Tordis A; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-03)<i>Background</i> - Saliva plays a significant role in maintaining oral health and oral bacterial milieu. Difference in oxidative stress (OS) levels in saliva in conjunction with bacterial load between pregnant and non-pregnant women has not been studied previously. We hypothesized that the physiological changes in pregnancy alter oral bacterial milieu by promoting growth of <i>Streptococcus mutans</i> ... -
Static and functional hemodynamic profiles of women with abnormal uterine artery doppler at 22-24 weeks of gestation
Vårtun, Åse; Flo, Kari; Widnes, Christian; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)Objective To compare cardiac function, systemic hemodynamics and preload reserve of women with increased (cases) and normal (controls) uterine artery (UtA) pulsatility index (PI) at 22–24 weeks of gestation. Materials and Methods A prospective cross-sectional study of 620 pregnant women. UtA blood flow velocities were measured using Doppler ultrasonography, and PI was calculated. Mean UtA ...